The Research

RestoraPet’s key ingredients have been the subject of 2,470 peer reviewed clinical trials and research studies (and counting) since 2008. All studies were published in peer-reviewed journals and indexed by PubMed.

The following are just some of the many studies documenting the effects of RestoraPet’s critically important ingredients:

Vitalitrol™:

– Increased energy by restoring mitochondrial functioning [1], [2], [3]
– Prolongation of lifespan [4]
– Protection of vital organs [4]
– Effects on Endogenous Antioxidant Systems: Glutathione, Superoxidismutase and Catalase Activities [4]
– Prevention of cancer [5]
– Safety and non-toxicity [6]

Ubiquinol (CoQ10):

– Healthy circulation [7], [8]
– Energy [9], [10]
– Immune function [11]
– Gastrointestinal health [12]
– Healthy gums [13], [14]

All 8 Tocopherols and Tocotrienols (Complete Vitamin E):

– Healthy immune system [15], [16]
– Cardiovascular health [17], [18]
– Connective tissue health [19], [20], [21]
– Cellular health [22], [23],
– Respiratory health [24]

EPA/DHA (Omega-3):

– Healthy coat and skin [25], [26], [27]
– Reduced inflammation [28], [29]
– Healthy immune system [30], [31]
– Lower blood pressure and triglycerides [32], [33]
– Healthy weight [34]

Lutein & Zeaxanthin:

– Eye health [35], [36]
– Prevention of cataracts [37]
– Healthy immune system [38], [39]
Omega-6 (Linoleic Acid)
– Healthy coat and skin [40]
– Reduced inflammation [41]
– Immune system regulation [42]

 

[1] Foley, S., Crowley, C., Smaihi, M., Bonfils, C., Erlanger, B. F., Seta, P., & Larroque, C. (2002). Cellular localisation of a water-soluble fullerene derivative. Biochemical and biophysical research communications, 294(1), 116-119.

[2] Cai, X., Hao, J., Zhang, X., Yu, B., Ren, J., Luo, C., … & Liu, J. (2010). The polyhydroxylated fullerene derivative C60 protects mice from ionizing-radiation-induced immune and mitochondrial dysfunction. Toxicology and applied pharmacology, 243(1), 27-34.

[3] Ueng, T. H., Kang, J. J., Wang, H. W., Cheng, Y. W., & Chiang, L. Y. (1997). Suppression of microsomal cytochrome P450-dependent monooxygenases and mitochondrial oxidative phosphorylation by fullerenol, a polyhydroxylated fullerene C60. Toxicology letters, 93(1), 29-37.

[4] Baati, Tarek, et al. “The prolongation of the lifespan of rats by repeated oral administration of [60] fullerene.” Biomaterials 33.19 (2012): 4936-4946.

[5] Prylutska, S. V., et al. “Pristine C (60) fullerenes inhibit the rate of tumor growth and metastasis.” Exp Oncol 33.3 (2011): 162-164.

[6] Takahashi, Mika, et al. “Sub-acute oral toxicity study with fullerene C60 in rats.” Journal of Toxicological Sciences 37.2 (2012).

[7] Chang, A. Y., Chan, J. Y., Chuang, Y. C., & Chan, S. H. (2009). Brain stem death as the vital determinant for resumption of spontaneous circulation after cardiac arrest in rats. PloS one, 4(11), e7744.

[8] Leelarungrayub, D., Sawattikanon, N., Klaphajone, J., Pothongsunan, P., & Bloomer, R. J. (2010). Coenzyme Q10 supplementation decreases oxidative stress and improves physical performance in young swimmers; a pilot study. The Open Sports Med J, 4, 1-8.

[9] Marubayashi, S., Dohi, K., Ezaki, H., Hayashi, K., & Kawasaki, T. (1982). Preservation of ischemic rat liver mitochondrial functions and liver viability with CoQ10. Surgery, 91(6), 631-637.

[10] Zheng, A., & Moritani, T. (2008). Influence of CoQ10 on autonomic nervous activity and energy metabolism during exercise in healthy subjects. Journal of nutritional science and vitaminology, 54(4), 286-290.

[11] Dighe, N. S., Pattan, S. R., Gaware, V. M., Hole, M. B., Musmade, D. S., Kale, S. H., & Waman, S. (2010). COQ10 A wonder enzyme: a review. Pharma Chem, 2, 236-250.

[12] Samini, H. S., Mousavi, Z., & S Shirazi–Beheshtiha, S. (2012). Effects of coenzyme Q10 and vitamin C on the indomethacin–induced gastric ulcer in rat: A controlled experimental study. Research in Pharmaceutical Sciences, 7(5), S44.

[13] Ryo, K., Ito, A., Takatori, R., Tai, Y., Arikawa, K., Seido, T., … & Saito, I. (2011). Effects of coenzyme Q10 on salivary secretion. Clinical biochemistry, 44(8), 669-674.

[14] Prakash, S., Sunitha, J., & Hans, M. (2010). Role of coenzyme Q10 as an antioxidant and bioenergizer in periodontal diseases. Indian journal of pharmacology, 42(6), 334.

[15] Bendich, A., Gabriel, E., & Machlin, L. J. (1986). Dietary vitamin E requirement for optimum immune responses in the rat. The Journal of nutrition, 116(4), 675-681.

[16] Leshchinsky, T. V., & Klasing, K. C. (2001). Relationship between the level of dietary vitamin E and the immune response of broiler chickens. Poultry Science, 80(11), 1590-1599.

[17] Patrick, L., & Uzick, M. (2001). Cardiovascular disease: C-reactive protein and the inflammatory disease paradigm: HMG-CoA reductase inhibitors, alpha-tocopherol, red yeast rice, and olive oil polyphenols. A review of the literature. Alternative medicine review: a journal of clinical therapeutic, 6(3), 248-271.

[18] Sylvester, P. W., & Theriault, A. (2003). Role of tocotrienols in the prevention of cardiovascular disease and breast cancer. Current Topics in Nutraceutical Research, 1, 121-136.

[19] Knekt, P., Heliövaara, M., Aho, K., Alfthan, G., Marniemi, J., & Aromaa, A. (2000). Serum selenium, serum alpha-tocopherol, and the risk of rheumatoid arthritis. Epidemiology, 11(4), 402-405.

[20] Villacorta, L., Graça-Souza, A. V., Ricciarelli, R., Zingg, J. M., & Azzi, A. (2003). α-Tocopherol induces expression of connective tissue growth factor and antagonizes tumor necrosis factor-α–mediated downregulation in human smooth muscle cells. Circulation research, 92(1), 104-110.

[21] Azzi, A., Gysin, R., Kempna, P., Ricciarelli, R., Villacorta, L., Visarius, T., & Zingg, J. M. (2003). The role of α-tocopherol in preventing disease: from epidemiology to molecular events. Molecular aspects of medicine, 24(6), 325-336.

[22] Xu, Z., Hua, N., & Godber, J. S. (2001). Antioxidant activity of tocopherols, tocotrienols, and γ-oryzanol components from rice bran against cholesterol oxidation accelerated by 2, 2′-azobis (2-methylpropionamidine) dihydrochloride. Journal of Agricultural and Food Chemistry, 49(4), 2077-2081.

[23] Meydani S, Meydani M, Blumberg JB, et al. Vitamin E Supplementation and In Vivo Immune Response in Healthy Elderly Subjects: A Randomized Controlled Trial. JAMA. 1997;277(17):1380-1386.

[24] Cross, C. E., Forte, T., Stocker, R., Louie, S., Yamamoto, Y., Ames, B. N., & Frei, B. (1990). Oxidative stress and abnormal cholesterol metabolism in patients with adult respiratory distress syndrome. The Journal of laboratory and clinical medicine, 115(4), 396-404.

[25] Mueller, R. S., Fieseler, K. V., Fettman, M. J., Zabel, S., Rosychuk, R. A. W., Ogilvie, G. K., & Greenwalt, T. L. (2004). Effect of omega‐3 fatty acids on canine atopic dermatitis. Journal of small animal practice, 45(6), 293-297.

[26] Boelsma, E., Hendriks, H. F., & Roza, L. (2001). Nutritional skin care: health effects of micronutrients and fatty acids. The American journal of clinical nutrition, 73(5), 853-864.

[27] Logas, D., & Kunkle, G. A. (1994). Double‐blinded Crossover Study with Marine Oil Supplementation Containing High‐dose icosapentaenoic Acid for the Treatment of Canine Pruritic Skin Disease*. Veterinary Dermatology, 5(3), 99-104.

[28] Li, H., Ruan, X. Z., Powis, S. H., Fernando, R., Mon, W. Y., Wheeler, D. C., … & Varghese, Z. (2005). EPA and DHA reduce LPS-induced inflammation responses in HK-2 cells: Evidence for a PPAR-γ–dependent mechanism. Kidney international, 67(3), 867-874.

[29] James, M. J., Gibson, R. A., & Cleland, L. G. (2000). Dietary polyunsaturated fatty acids and inflammatory mediator production. The American journal of clinical nutrition, 71(1), 343s-348s.

[30] Wander, R. C., Hall, J. A., Gradin, J. L., Du, S. H., & Jewell, D. E. (1997). The ratio of dietary (n-6) to (n-3) fatty acids influences immune system function, eicosanoid metabolism, lipid peroxidation and vitamin E status in aged dogs. The Journal of nutrition, 127(6), 1198-1205.

[31] Bauer, J. E. (2007). Responses of dogs to dietary omega-3 fatty acids. Journal of the American Veterinary Medical Association, 231(11), 1657-1661.

[32] Bucher, H. C., Hengstler, P., Schindler, C., & Meier, G. (2002). N-3 polyunsaturated fatty acids in coronary heart disease: a meta-analysis of randomized controlled trials. The American journal of medicine, 112(4), 298-304.

[33] Billman, G. E., Kang, J. X., & Leaf, A. (1997). Prevention of ischemia-induced cardiac sudden death by n− 3 polyunsaturated fatty acids in dogs. Lipids, 32(11), 1161-1168.

[34] Ruzickova, J., Rossmeisl, M., Prazak, T., Flachs, P., Sponarova, J., Vecka, M., … & Kopecky, J. (2004). Omega-3 PUFA of marine origin limit diet-induced obesity in mice by reducing cellularity of adipose tissue. Lipids, 39(12), 1177-1185.

[35] Krinsky, N. I., Landrum, J. T., & Bone, R. A. (2003). Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye. Annual review of nutrition, 23(1), 171-201.

[36] Moeller, S. M., Parekh, N., Tinker, L., Ritenbaugh, C., Blodi, B., Wallace, R. B., & Mares, J. A. (2006). Associations between intermediate age-related macular degeneration and lutein and zeaxanthin in the Carotenoids in Age-related Eye Disease Study (CAREDS): ancillary study of the Women’s Health Initiative. Archives of ophthalmology, 124(8), 1151-1162.

[37] Williams, D. L. (2006). Oxidation, antioxidants and cataract formation: a literature review. Veterinary ophthalmology, 9(5), 292-298.

[38] Kim, H. W., Chew, B. P., Wong, T. S., Park, J. S., Weng, B. B., Byrne, K. M., … & Reinhart, G. A. (2000). Dietary lutein stimulates immune response in the canine. Veterinary immunology and immunopathology, 74(3), 315-327.

[39] Ribaya-Mercado, J. D., & Blumberg, J. B. (2004). Lutein and zeaxanthin and their potential roles in disease prevention. Journal of the American College of Nutrition, 23(sup6), 567S-587S.

[40] Saevik, B. K., Bergvalll, K., Holm, B. R., Saijonmaa-Koulumies, L. E., Hedhammar, Å., Larsen, S., & Kristensen, F. (2004). A randomized, controlled study to evaluate the steroid sparing effect of essential fatty acid supplementation in the treatment of canine atopic dermatitis. Veterinary dermatology, 15(3), 137-145.

[41] Wang, L. S., Huang, Y. W., Liu, S., Chang, H. L., Ye, W., Shu, S., … & Lin, Y. C. (2006). Conjugated linoleic acid (CLA) modulates prostaglandin E2 (PGE2) signaling in canine mammary cells. Anticancer research, 26(2A), 889-898.

[42] Dall’Ara, P. (2003). Immune system and ageing in the dog: Possible consequences and control strategies. Veterinary research communications, 27, 535-542.

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